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    咨询热线:400-002-5225
    专家风采 > 刘文军

    刘文军

    专家姓名:刘文军
    职称职务:中国科学院病原微生物与免疫学重点实验室副主任 研究员
    中国科学院生物安全三级实验室主任
    中国科学院分子病毒中心主任
    中关村科技园区分子病毒及生物制药开放实验室主任
    中国科学院“百人计划”获得者
    分子感染与生物制药 
    组长:刘文军  研究员
    研究方向:病毒与宿主细胞相互作用、动物病毒分子进化以及新型免疫增强剂和抗病毒药物
    主要履历及经历
    1978.03-1982.12北京农业大学兽医学院,兽医专业,学士
    1982.08-1985.08北京农业大学兽医学院,动物组织胚胎学,硕士
    1982.08-1985.08北京农业大学实验动物研究所,研究所助理,讲师
    1991.05-1996.05美国佛罗里达大学,分子和细胞生物学博士
    1988.08-1989.08美国国立动物病研究中心,客座科学家
    1995.05-1998.03美国Oklahoma大学医学中心,博士后
    1998.03-2000.12美国哈佛休斯医学研究所,Research Associate
    2000.01-2004.08美国GENZYME 公司,高级科学家
    2004.10-至今中国科学院病原微生物与免疫学重点实验室副主任,生物安全三级实验室主任,分子病毒中心主任,中关村科技园区分子病毒及生物制药开放实验室主任,研究员、博士生导师
     
    发表论文(自2005年):
            1. M-R Yu#, X-L Liu#, Sh Cao, Zh-D Zhao, K Zhang, Q Xie, C-W Chen, Sh-Y Gao, Y-H Bi, L Sun, X Ye, George F. Gao, W-J Liu*. 2012. Identification and Characterization of three novel nuclear export signals in influenza A virus nucleoprotein. Journal of Virology (online, doi: 10.1128/JVI.06159-11.)
            2. Sh CaoX-L LiuM-R YuJ LiX-J JiaY-H BiL SunGeorge F. GaoW-J Liu*. 2012. A Nuclear Export Signal in the Matrix Protein of Influenza A Virus Is Required for the Efficient Virus Replication. Journal of Virology (online, doi: 10.1128/JVI.06586-11.)
            3. X-L Liu#, Zh-D Zhao#, Ch-F Xu, L Sun, J-L Chen, L-F Zhang, W-J Liu*. 2012. Cyclophilin A Restricts Influenza A Virus Replication through Degradation of the M1 Protein. PLoS ONE 7(2): e31063. doi:10.1371/journal.pone.0031063.
            4. J Liu#, L-P Dai#, J-X Qi, F Gao, Y-J Feng, W-J Liu, J-H Yan*, George F. Gao, 2011, Diverse peptide presentation of rhesus macaque MHC class I Mamu-A*02 revealed by two peptide-complex structures and insights into SIV immune escape. Journal of Virology, 85(14):7372-83
            5. X-L Yan#, X-J Zhang#, Y-ZH Wang, X-H Li, S-F Wang, B Zhao, Y Li, Y Ju, L-ZH Chen, W-J Liu, S-D Meng. 2011. Regulatory T Cell Depletion Synergizes With gp96 Mediated Cellular Responses and Antitumor Activity. Cancer Immunology, Immunotherapy (online, doi: 10.1007/s00262-011-1076-5)
            6. Z-F Wang, X-L Liu, Z-D Zhao, C-F Xu, K Zhang, C-W Chen, L Sun, F Gao, X Ye, W-J Liu*, 2011, Cyclophilin E functions as a negative regulator to influenza virus replication by impairing the formation of the ribonucleoprotein complex. PLoS ONE 6(8): e22625. doi:10.1371/journal.pone.0022625
            8. S-S Meng, L-M Yang, C-F Xu, Z-M Qin, H-Y Xu, Y-L Wang, L Sun and W-J Liu*. Recombinant Chicken Interferon-α Inhibits H9N2 Avian Influenza Virus Replication in vivo by Oral Administration. Journal of Interferon and Cytokine Research. 2011, 7;31(7):533-8
            9. Y-H Bi#, L Lu#, J Li, Y-B Yin, Y Zhang, H-J Gao, Zh-M Qin, Basit Zeshan, J-H Liu, W-J Liu*, L Sun*. Novel genetic reassortants in H9N2 influenza A Viruses and the diverse pathogenicity to mice. Virology Journal, 2011, 8:505
           10. L Lu, Y-B Yin, Z-S Sun, L Gao, F Gao, S-D Liu, L Sun* and W-J Liu*. 2010. Genetic correlation between current circulating H1N1 swine and human influenza viruses. Journal of Clinical Virology. 49(3): 186-91.
           11. M-R Yu, X-L Liu, L Sun, C-W Chen, G-P Ma, Y. Kitamura, F Gao andW-J Liu*. 2010. Subcellular localization and topology of porcine reproductive and respiratory syndrome virus E protein. Virus Research. 152(1-2): 104-14.
           12. C-F Xu, S-S Meng, X-L Liu, L Sun and W-J Liu*. 2010. Chicken Cyclophilin A is an inhibitory factor to influenza virus replication. Virology Journal. 7(1): 372.
           13. Q-H Xue, L-M Yang, X-L Liu and W-J Liu*. 2010. Molecular characterization of feline interferon receptor 2. Journal of Interferon and Cytokine Research.30(2): 81-8.
           14. L Sun, G-H Zhang, Y-L Shu, X-M Chen, Y-P Zhu, L-M Yang, G-P Ma, Y.Kitamura and W-J Liu*. 2009. Genetic correlation between H3N2 human and swine influenza viruses. Journal of Clinical Virology. 44(2): 141-4.
           15. X-L Liu, L Sun, M-R Yu, Z-F Wang, C-F Xu, Q-H Xue, K Zhang, X Ye, Y. Kitamura and W-J Liu*. 2009. Cyclophilin A interacts with influenza A virus M1 protein and impairs the early stage of the viral replication. Cellular Microbiology. 11(5): 730-41.
           16. J-J Zhang, G Li, X-L Liu, Z-F Wang, W-J Liu* and X Ye*. 2009. Influenza A virus M1 blocks the classical complement pathway through interacting with C1qA. Journal of General Virology. 90(11): 2751-8.
           17. D Liu, X-L Liu, J-H Yan, W-J Liu* and F. Gao*. 2009. Interspecies transmission and host restriction of avian H5N1 influenza virus. Science in China Series C: Life Science. 52(5): 428–38.
           18. Z-M Qin, L Sun, B-C Ma, Z-Z Cui, Y-P Zhu, Yoshihiro Kitamura and W-J Liu*. 2008. F gene recombination between genotype II and VII Newcastle disease virus. Virus Research. 131(2): 299-303.
           19. L-T Tan, H-Y Xu, Y-L Wang, Z-M Qin*, L Sun, W-J Liu and Z-Z Cui. 2008. Molecular characterization of three new virulent Newcastle disease virus (NDV) variants isolated from China. Journal of Clinical Microbiology. 46(2): 750-3.
           20. Z-M Qin*, L-T Tan, H-Y Xu, B-C Ma, Y-L Wang, X-Y Yuan and W-J Liu*. 2008. Pathotypical characterization and molecular epidemiology of Newcastle disease virus Isolates from different hosts in China from 1996 to 2005. Journal of Clinical Microbiology. 46(2): 601-11.
           21. L Sun, G-H Zhang, J-W Jiang, J-D Fu, T Ren, W-S Cao, C-A Xin, M Liao and W-J Liu*. 2007. A massachusetts prototype like coronavirus isolated from wild peafowls is pathogenic to chickens. Virus Research. 130(1-2): 121-8.
           22. L-M Yang Q-H Xue, L Sun, Y-P Zhu and W-J Liu*. 2007. Cloning and characterization of a novel feline IFN-ω. Journal of Interferon and Cytokine Research. 27(2): 119-27.
           23. L-M Yang, L-Z Zhao, R-L Hu, Z-S Shi, and W-J Liu*. 2006. A novel double-antigen sandwich enzyme-linked immunosorbent assay for measurement of antibodies against rabies virus. Clinical and Vaccine Immunology. 13(8): 966-8.
           24. J Liu*, H Xiao, F Lei, Q Zhu, K Qin, X-W Zhang, X-L Zhang, D Zhao, Q Wang, L Feng, J Ma, W-J Liu and F Gao*. 2005. Highly pathogenic H5N1 influenza virus infection in migratory birds. Science. 309 (5738): 1206 .
     
    发明及申请专利
     
    1     一种猫α干扰素及其编码基因与其应用
    2     一种检测狂犬病病毒的酶联免疫试剂盒
    3     猪γ干扰素及其编码基因与应用
    4     一种改良重组猪α干扰素蛋白及其编码基因与应用
    5     猫ω干扰素及其编码基因与应用
    6     猪用抗原呈递蛋白及其编码基因和应用
    7     一种预防猪生殖与呼吸综合征的疫苗
    8     预防鸭病毒性肝炎的灭活疫苗及其制备方法
    9     编码鸡α干扰素的优化基因及其在制备鸡α干扰素中的应用
    10    检测H1亚型猪流感病毒抗体的蛋白及其应用
    11    优化的草鱼α干扰素编码基因及其应用
    12    一种猪链球菌2型本动物感染模型的构建方法
    13    预防鸭病毒性肝炎的灭活疫苗及其制备方法
    14    辅助鉴定猪链球菌2型与猪链球菌7型的专用引物及其应用
    15    鸡源热休克蛋白及其编码基因和应用
    16    多肽片段组合物及其在制备猪繁殖与呼吸综合征疫苗中的应用
    17    一株鸡源H9N2禽流感病毒毒株及其应用
    18    特异多肽在制备狂犬病疫苗中的应用


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